Basic Science Research Areas
Cancer Prevention and Control
Nutrition, dietary and chemopreventive factors and their use in intervention for cancer risk, and inhibition of cancer progression. Emphasis is on basic mechanistic studies, preclinical and clinical (phase-I and phase-II) studies as well as discovery, evaluation, and validation of dietary factors.
Developmental Therapeutics and Clinical Trials
Faculty study the experimental therapy of neoplastic diseases in in vitro systems and in vivo model systems, including some early-stage, pilot clinical trials. The major emphasis is on the rational development of novel therapeutic strategies that have a significant potential for early translation to the clinic.
Early Cancer Detection and Imaging
The application and validation of in vivo imaging of cancer in humans and animals, including early phase clinical studies of medical imaging systems, molecular probes and contrast agents, software, molecular imaging techniques, and related technologies. The underlying technologies are refined and optimized during testing in response to research questions or clinical needs.
Basic mechanisms of interactions between tumor and host system including stromal cells, extracellular matrix (ECM) and extracellular molecules. Emphasis is on evaluation of the tumor as an organ-like structure with complex, dynamic cross-talk. Studies of tumor-stroma interactions including cell-cell interaction, tumor induced alterations of ECM and organ specific metastasis.
Tumor Progression and Metastasis
The basic mechanisms of cancer progression, metastasis, invasion/migration and angiogenesis. Special emphasis is placed on hypoxia, adhesion, and growth. Studies focusing on integrins, cytoskeleton, proteases, extracellular matrix remodeling, suppressors/inhibitors of metastasis and angiogenesis, and animal models of metastasis are used with links to more translational studies using human cells.