Tumor Progression and Metastasis

The basic mechanisms of cancer progression, metastasis, invasion/migration and angiogenesis. Special emphasis is placed on hypoxia, adhesion, and growth. Studies focusing on integrins, cytoskeleton, proteases, extracellular matrix remodeling, suppressors/inhibitors of metastasis and angiogenesis, and animal models of metastasis are used with links to more translational studies using human cells.